Trial to study the antibacterial effect of quercetin nanoparticles (QUENPS) on drug- resistant E. coli strains in rabbits

The present study aimed to evaluate the antibacterial effect and antioxidant potential of quercetin nanoparticles on drug-resistant E. coli O157 in New Zealand White Rabbits. Initial surveillance lasting two years (2018-2019) was performed isolate molecular detection some virulence genes drug-resistant E.coli strains circulating NZW rabbits Egypt.The selected E.coli O157 strain our experimental work produced strong biofilm sxt1 (MN902223), sxt2 (MT832770) eaeA (MN813493) (similarities were 99-100% compared other E. gene bank). most important results showed that treated with neither clinical signs nor post mortem lesions. E. re-isolated only at 3 dPI comparison other infected groups. groups nano-quercetin a significant increase enzymes before after infection quercetin, highest activity GPX SOD level appeared group 10 dPI, while lowest MDA NQ There no changes biochemical parameters except decrease total cholesterol 3,10 dPI. In conclusion, Quercetin could be used as preventive therapeutic agent powerful drug for protection against E. coli O157.